ISTO Biologics: Pioneering the Future of Regenerative Medicine
Innovative Solutions for Superior Healing
ISTO Biologics is a leader in regenerative medicine, providing cutting-edge biologic solutions that enhance bone healing and tissue repair. Designed for orthopedic surgeons, spine surgeons, and sports medicine specialists, our advanced cell-based therapies and bioactive technologies set a new standard in patient
ISTO Biologics offers a comprehensive portfolio of regenerative solutions, including the Magellan Autologous Concentration System, Precise™ Precision Targeting for PRP, and Allografts. Each technology is designed to optimize healing, tissue repair, and patient outcomes in orthopedics, spine surgery, sports medicine, and regenerative medicine.
Orthobiologic solutions to
help your patients heal faster.
Why Choose ISTO Biologics?
✅Next-Generation Biologics – Scientifically engineered to optimize osteoinductive and osteoconductive properties for faster healing.
✅ Clinically Proven – Backed by rigorous research and real-world clinical success.
✅ Surgeon-Driven Innovation – Developed with direct input from leading specialists to meet the demands of modern medicine.
✅ Uncompromising Quality – High processing standards ensure safety, efficacy, and reliability.
Regenerative Solutions for Specialized Care
🔹 Orthopedics – Advanced biologics to accelerate bone healing and joint restoration.
🔹 Spine Surgery – Innovative grafting solutions to improve fusion success rates.
🔹 Sports Medicine – Regenerative therapies designed to enhance soft tissue and cartilage repair.
What is an autologous concentration system?
Autologous concentration systems can process a patient’s blood or other biological fluids to extract and concentrate specific components such as platelets, growth factors, and stem cells. The resulting concentrations can then be applied to targeted areas of the body where it can promote healing and tissue regeneration.
Isto's Magellan Autologous Concentration System is designed for use with kits that can produce final outputs of:
The Magellan® MAR0Max™ Kit
The Magellan® MAR0Max™ Kit provides the surgeon everything needed to Aspirate, Concentrate and Deliver a mixture of whole blood and bone marrow. Bone marrow is rich in platelets, nucleated and progenitor cells.
Baseline (Undiluted Bone Marrow) Concentrate (BMA = Bone Marrow Aspirate) (Refer to chart on right.) Mesenchymal Stem Cell (MSC) Hematopoietic Stem Cell (HSC) AMSI Source: TS-001A-008 Benefits S Autologous S Easy to Use S Consistent, Reproducible, Reliable Results S Up to 3 Spins Per Disposable for a Single Patient S Fully Closed System S Completely Automated Customized
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and optimize results
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97%
5-6x
94%
Baseline (Undiluted Bone Marrow) Concentrate (BMA = Bone Marrow Aspirate) (Refer to chart on right.) Mesenchymal Stem Cell (MSC) Hematopoietic Stem Cell (HSC) AMSI Source: TS-001A-008 Benefits S Autologous S Easy to Use S Consistent, Reproducible, Reliable Results S Up to 3 Spins Per Disposable for a Single Patient S Fully Closed System S Completely Automated Customized
Fully Automated
Simple one-button start for ease of use________________________________________________
Closed System
Minimal breaks in sterile barrier promote safety________________________________________________
BioAdaptive Processing
Works with optical sensors to tailor processing parameters based on each patient’s hematocrit________________________________________________
Optical Sensors
Identify the cellular fraction to eliminate errorand optimize results
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Selectable Output
Allows users to define desired therapeutic volumes (3-10 mL per cycle)Product Outputs
The human body has built in repair mechanisms (platelets, nucleated cells, growth factors, signaling proteins) to recover from tissue injury. Concentrating those cells at the bedside and delivering to an injury site may be beneficial in conjunction with the body's healing process.Platelet Rich Plasma From whole blood
Platelet Rich Plasma (PRP) therapy provides a concentration of a patient’s own platelets to accelerate the healing of injured tissues.Concentration Process
Magellan allows clinicians to customize output volumes and concentration factors to meet their patients’ specific needs.- A single kit will process 30-60 mL of bone marrow and/or blood to produce a user-defined output volume, ranging between 3-10 mL.
- Each kit is processed three times per patient, offering clinicians a cost-effective solution for processing bone marrow and/or blood.
- Both PRP and MAR0 kits are available for use with the Magellan system.
Proven to Concentrate Viable Progenitor Cells
Data featuring Magellan MAR0Max demonstrates increased concentrations of MSCs & HSCs97%
Cell Viability1
5-6x
MSC & HSC Concentration2
94%
Reduction in Red Blood Cells (RBC)2,3
Autologous Therapies
From the patient, for the patient.
Precision Targeting for PRP
Concentrate without Compromise
Precise™ is a brand new, state of the art technology that delivers a final PRP product with precision cellular fractions upon concentration.
Meet Precise
Designed to keep patient and physician needs front and center, Precise™ allows for the removal of specific cell types without compromising platelet concentrations. Whether you’re looking for a Leukocyte Rich (LR) or Leukocyte Poor (LP) PRP, Precise™ has you covered.
Simplicity
In a single spin, Precise delivers what you want and removes what you don’t want, all while eliminating a mid-process interruption.
Flexibility
A Precise disposable can process between 30-60 ml of whole blood in a single 12-minute cycle. (eventually able to process up to 240 in one spin-think 120 PRP, 120 marrow.)
Versatility
The system’s CellectFlex™ Technology allows for tailored cell compositions with each spin, allowing the system to provide a targeted range of offerings that have never been available before.
User-Friendly System
Built with you in mind, the Precise system was designed to decrease the risk of user error. Each single-use disposable kit is compatible with a thoughtfully designed extraction stand that simplifies obtaining finely tuned final volumes of cellular fractions.
Precision Targeting for Patient CarePrecise can achieve high platelet concentrations and desired monocyte levels while maintaining maximum reduction in red blood cells and granulocytes found in LP PRP. Final outputs maintain platelet concentrations above established therapeutic levels.
Competitive Advantages of ISTO Precision
Targeting for PRP – Precise™
1️⃣ Concentrate Without Compromise – Unlike traditional PRP systems, Precise™ ensures optimal concentration of platelets while preserving essential cellular components, leading to superior regenerative potential.
2️⃣ Precision Cellular Fractions – This state-of-the-art technology delivers a final PRP product with carefully controlled cellular composition, ensuring the highest therapeutic efficacy for tissue healing and repair.
3️⃣ Higher Platelet Recovery – Precise™ maximizes platelet yield and minimizes unwanted components, providing greater regenerative impact compared to standard centrifuge-based PRP systems.
4️⃣ Enhanced Growth Factor Retention – By refining the PRP preparation process, Precise™ maintains optimal levels of growth factors, essential for accelerating tissue repair, reducing inflammation, and improving recovery times.
5️⃣ Consistent & Reproducible Results – The advanced Precision Targeting Technology ensures that each PRP preparation is consistent and reproducible, eliminating variability and enhancing treatment outcomes.
6️⃣ Broad Clinical Application – Ideal for orthopedic surgeons, sports medicine specialists, pain management physicians, and regenerative medicine practitioners, offering a versatile solution for a wide range of musculoskeletal conditions.
7️⃣ User-Friendly & Efficient – Designed for ease of use, Precise™ integrates seamlessly into clinical workflows, requiring minimal training while delivering rapid, high-quality PRP preparation.
8️⃣ Backed by Cutting-Edge Research – ISTO Biologics continuously invests in research and development, ensuring Precise™ remains at the forefront of PRP innovation.
9️⃣ Maximized Patient Outcomes – By optimizing platelet concentration, cellular fractioning, and growth factor retention, Precise™ helps clinicians achieve faster healing, reduced downtime, and improved patient satisfaction.
10️⃣ Competitive Edge in Regenerative Medicine – With its superior precision and reliability, Precise™ positions clinics and practitioners at the leading edge of PRP therapy, differentiating them in a rapidly growing regenerative medicine market.
2️⃣ Precision Cellular Fractions – This state-of-the-art technology delivers a final PRP product with carefully controlled cellular composition, ensuring the highest therapeutic efficacy for tissue healing and repair.
3️⃣ Higher Platelet Recovery – Precise™ maximizes platelet yield and minimizes unwanted components, providing greater regenerative impact compared to standard centrifuge-based PRP systems.
4️⃣ Enhanced Growth Factor Retention – By refining the PRP preparation process, Precise™ maintains optimal levels of growth factors, essential for accelerating tissue repair, reducing inflammation, and improving recovery times.
5️⃣ Consistent & Reproducible Results – The advanced Precision Targeting Technology ensures that each PRP preparation is consistent and reproducible, eliminating variability and enhancing treatment outcomes.
6️⃣ Broad Clinical Application – Ideal for orthopedic surgeons, sports medicine specialists, pain management physicians, and regenerative medicine practitioners, offering a versatile solution for a wide range of musculoskeletal conditions.
7️⃣ User-Friendly & Efficient – Designed for ease of use, Precise™ integrates seamlessly into clinical workflows, requiring minimal training while delivering rapid, high-quality PRP preparation.
8️⃣ Backed by Cutting-Edge Research – ISTO Biologics continuously invests in research and development, ensuring Precise™ remains at the forefront of PRP innovation.
9️⃣ Maximized Patient Outcomes – By optimizing platelet concentration, cellular fractioning, and growth factor retention, Precise™ helps clinicians achieve faster healing, reduced downtime, and improved patient satisfaction.
10️⃣ Competitive Edge in Regenerative Medicine – With its superior precision and reliability, Precise™ positions clinics and practitioners at the leading edge of PRP therapy, differentiating them in a rapidly growing regenerative medicine market.
Allograft Solutions
Isto Biologics offers three types of allografts designed with different characteristics to help your patients heal faster.
Grafts derived from donor tissue.
What is a Demineralized Bone Matrix?
DBMs are made from human bone that has been processed to remove its mineral content while preserving the collagen and growth factors. This results in a graft that is rich in bone morphogenetic proteins (BMPs) and other growth factors, which promote bone growth and regeneration.
Isto offers a variety of DBMs through the various Influx product lines, and come in multiple forms including:
Loose Fibers
Strips
Putty
Boats
Discs
Blocks
Why Providers Should Use ISTO Allografts
ISTO Biologics' allografts, derived from carefully screened donor tissue, offer exceptional quality, safety, and efficacy for a wide range of orthopedic and regenerative applications.
Here’s why providers should choose ISTO Allografts:
✅ Uncompromising Quality & Safety
- Rigorous Screening & Processing – All donor tissue undergoes comprehensive testing and is processed using strict quality control measures to ensure safety and reliability.
- Sterile & Ready-to-Use – ISTO allografts are aseptically processed to maintain biological integrity while eliminating contaminants.
📈 Clinically Effective for Bone Healing & Regeneration
- High Osteoconductive Potential – Provides a natural scaffold that promotes bone remodeling and integration.
- Versatile Applications – Ideal for spine, orthopedic, trauma, and sports medicine procedures, including fusion, joint restoration, and defect filling.
🔬 Advanced Processing Technology
- Preserves Native Growth Factors – ISTO's processing techniques retain essential growth factors to enhance healing and cellular response.
- Customizable Graft Options – Available in various forms, including cortical, cancellous, demineralized bone matrix (DBM), and structural grafts, to meet diverse surgical needs.
🦴 Trusted by Surgeons for Proven Performance
- Backed by Research & Clinical Use – ISTO allografts are supported by clinical studies and trusted by leading specialists in orthopedics, spine surgery, and regenerative medicine.
- Consistent & Reliable Results – Every graft is processed with high precision to ensure optimal handling characteristics and effectiveness in surgery.
💡 Elevate Patient Care with ISTO Allografts
By choosing ISTO allografts, providers gain a trusted, high-quality biologic solution designed to support better surgical outcomes and enhanced patient recovery.
💡 The ISTO Advantage
ISTO Biologics’ innovative regenerative solutions work together to provide clinicians with cutting-edge options for enhancing patient recovery, improving outcomes, and optimizing surgical success. Whether through autologous concentration, PRP precision targeting, or high-quality allografts, ISTO Biologics ensures clinicians have the best tools for regenerative medicine and orthopedic healing.
🔬 Magellan® Autologous Concentration System
Advanced Autologous Cell Therapy for Personalized Healing
✅ Customizable Concentration – Allows for precise control of platelet, stem cell, and growth factor levels, delivering personalized regenerative therapy.
✅ Closed-System Processing – Ensures sterile, safe, and efficient autologous biologic preparation for faster healing and tissue regeneration.
✅ Optimized for Multiple Specialties – Ideal for orthopedics, spine, wound care, and sports medicine, helping reduce recovery time and improve outcomes.
✅ Customizable Concentration – Allows for precise control of platelet, stem cell, and growth factor levels, delivering personalized regenerative therapy.
✅ Closed-System Processing – Ensures sterile, safe, and efficient autologous biologic preparation for faster healing and tissue regeneration.
✅ Optimized for Multiple Specialties – Ideal for orthopedics, spine, wound care, and sports medicine, helping reduce recovery time and improve outcomes.
🩸 Precise™ Precision Targeting for PRP
Next-Generation PRP with Optimal Cellular Fractions
✅ Concentrate Without Compromise – Achieves high platelet yield while maintaining essential cellular fractions for enhanced regenerative potential.
✅ Superior Growth Factor Retention – Maximizes healing potential by preserving bioactive components needed for tissue repair.
✅ Consistent & Reproducible Results – Provides clinicians with reliability and control, ensuring each PRP preparation delivers optimal therapeutic benefits.
✅ Concentrate Without Compromise – Achieves high platelet yield while maintaining essential cellular fractions for enhanced regenerative potential.
✅ Superior Growth Factor Retention – Maximizes healing potential by preserving bioactive components needed for tissue repair.
✅ Consistent & Reproducible Results – Provides clinicians with reliability and control, ensuring each PRP preparation delivers optimal therapeutic benefits.
🦴 ISTO Allografts – Grafts Derived from Donor Tissue
High-Quality Allografts for Bone Healing & Structural Support
✅ Rigorous Screening & Processing – Aseptic, high-quality donor tissue processed for maximum safety, reliability, and biocompatibility.
✅ Optimized Osteoconductivity & Osteoinductivity – Provides natural bone grafting solutions that integrate seamlessly into the patient’s body.
✅ Versatile Graft Options – Available in cortical, cancellous, demineralized bone matrix (DBM), and structural forms, supporting various surgical and regenerative applications.
✅ Rigorous Screening & Processing – Aseptic, high-quality donor tissue processed for maximum safety, reliability, and biocompatibility.
✅ Optimized Osteoconductivity & Osteoinductivity – Provides natural bone grafting solutions that integrate seamlessly into the patient’s body.
✅ Versatile Graft Options – Available in cortical, cancellous, demineralized bone matrix (DBM), and structural forms, supporting various surgical and regenerative applications.